Dataset Information
Single-particle cryo-EM micrographs of a chromatosome containing human linker histone H1.4
Ontology highlight
ABSTRACT:
SUBMITTER: Bing-Rui Zhou
PROVIDER: EMPIAR-10574 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms.
Molecular cell 20201124 1
The repeating structural unit of metazoan chromatin is the chromatosome, a nucleosome bound to a linker histone, H1. There are 11 human H1 isoforms with diverse cellular functions, but how they interact with the nucleosome remains elusive. Here, we determined the cryoelectron microscopy (cryo-EM) structures of chromatosomes containing 197 bp DNA and three different human H1 isoforms, respectively. The globular domains of all three H1 isoforms bound to the nucleosome dyad. However, the flanking/l ...[more]