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Human DPP9-CARD8 complex-VbP

ABSTRACT:

SUBMITTER: Hao Wu

PROVIDER: EMPIAR-10596 | biostudies-other |

REPOSITORIES: biostudies-other

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Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment.

Sharif Humayun H Hollingsworth L Robert LR Griswold Andrew R AR Hsiao Jeffrey C JC Wang Qinghui Q Bachovchin Daniel A DA Wu Hao H

Immunity 20210520 7

CARD8 detects intracellular danger signals and forms a caspase-1 activating inflammasome. Like the related inflammasome sensor NLRP1, CARD8 autoprocesses into noncovalently associated N-terminal (NT) and C-terminal (CT) fragments and binds the cellular dipeptidyl peptidases DPP8 and 9 (DPP8/9). Certain danger-associated signals, including the DPP8/9 inhibitor Val-boroPro (VbP) and HIV protease, induce proteasome-mediated NT degradation and thereby liberate the inflammasome-forming CT. Here, we r ...[more]

PMID: 34019797

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