Human NLRP1-DPP9-VbP complex
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ABSTRACT:
SUBMITTER: Hao Wu
PROVIDER: EMPIAR-10595 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Hollingsworth L Robert LR Sharif Humayun H Griswold Andrew R AR Fontana Pietro P Mintseris Julian J Dagbay Kevin B KB Paulo Joao A JA Gygi Steven P SP Bachovchin Daniel A DA Wu Hao H
Nature 20210317 7856
Nucleotide-binding domain and leucine-rich repeat pyrin-domain containing protein 1 (NLRP1) is an inflammasome sensor that mediates the activation of caspase-1 to induce cytokine maturation and pyroptosis<sup>1-4</sup>. Gain-of-function mutations of NLRP1 cause severe inflammatory diseases of the skin<sup>4-6</sup>. NLRP1 contains a function-to-find domain that auto-proteolyses into noncovalently associated subdomains<sup>7-9</sup>, and proteasomal degradation of the repressive N-terminal fragme ...[more]
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