Cryo EM Structure of the E. coli BcsB Hexamer
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ABSTRACT:
SUBMITTER: Jochen Zimmer
PROVIDER: EMPIAR-10626 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Molecular organization of the E. coli cellulose synthase macrocomplex.
Acheson Justin F JF Ho Ruoya R Goularte Nicolette F NF Cegelski Lynette L Zimmer Jochen J
Nature structural & molecular biology 20210311 3
Cellulose is frequently found in communities of sessile bacteria called biofilms. Escherichia coli and other enterobacteriaceae modify cellulose with phosphoethanolamine (pEtN) to promote host tissue adhesion. The E. coli pEtN cellulose biosynthesis machinery contains the catalytic BcsA-B complex that synthesizes and secretes cellulose, in addition to five other subunits. The membrane-anchored periplasmic BcsG subunit catalyzes pEtN modification. Here we present the structure of the roughly 1 MD ...[more]
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