Identification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses
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ABSTRACT:
SUBMITTER: Sarah Jane Butcher
PROVIDER: EMPIAR-10652 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Identification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses.
Flatt Justin W JW Domanska Aušra A Seppälä Alma L AL Butcher Sarah J SJ
Communications biology 20210226 1
Enteroviruses pose a persistent and widespread threat to human physical health, with no specific treatments available. Small molecule capsid binders have the potential to be developed as antivirals that prevent virus attachment and entry into host cells. To aid with broad-range drug development, we report here structures of coxsackieviruses B3 and B4 bound to different interprotomer-targeting capsid binders using single-particle cryo-EM. The EM density maps are beyond 3 Å resolution, providing d ...[more]
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