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TSC complex particles


ABSTRACT:

SUBMITTER: Christopher Herbert Stanley Aylett 

PROVIDER: EMPIAR-10704 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Architecture of the Tuberous Sclerosis Protein Complex.

Ramlaul Kailash K   Fu Wencheng W   Li Hua H   de Martin Garrido Natàlia N   He Lin L   Trivedi Manjari M   Cui Wei W   Aylett Christopher H S CHS   Wu Geng G  

Journal of molecular biology 20201208 2


The Tuberous Sclerosis Complex (TSC) protein complex (TSCC), comprising TSC1, TSC2, and TBC1D7, is widely recognised as a key integration hub for cell growth and intracellular stress signals upstream of the mammalian target of rapamycin complex 1 (mTORC1). The TSCC negatively regulates mTORC1 by acting as a GTPase-activating protein (GAP) towards the small GTPase Rheb. Both human TSC1 and TSC2 are important tumour suppressors, and mutations in them underlie the disease tuberous sclerosis. We use  ...[more]

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