Nucleolar maturation of the human small subunit processome
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ABSTRACT:
SUBMITTER: Arnaud Vanden Broeck
PROVIDER: EMPIAR-10781 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Nucleolar maturation of the human small subunit processome.
Singh Sameer S Vanden Broeck Arnaud A Miller Linamarie L Chaker-Margot Malik M Klinge Sebastian S
Science (New York, N.Y.) 20210910 6560
The human small subunit processome mediates early maturation of the small ribosomal subunit by coupling RNA folding to subsequent RNA cleavage and processing steps. We report the high-resolution cryo–electron microscopy structures of maturing human small subunit (SSU) processomes at resolutions of 2.7 to 3.9 angstroms. These structures reveal the molecular mechanisms that enable crucial progressions during SSU processome maturation. RNA folding states within these particles are communicated to a ...[more]
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