In situ X-ray assisted electron microscopy staining for large biological samples
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ABSTRACT:
SUBMITTER: Adrian Andreas Wanner
PROVIDER: EMPIAR-10782 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
In situ X-ray-assisted electron microscopy staining for large biological samples.
Ströh Sebastian S Hammerschmith Eric W EW Tank David W DW Seung H Sebastian HS Wanner Adrian Andreas AA
eLife 20221020
Electron microscopy of biological tissue has recently seen an unprecedented increase in imaging throughput moving the ultrastructural analysis of large tissue blocks such as whole brains into the realm of the feasible. However, homogeneous, high-quality electron microscopy staining of large biological samples is still a major challenge. To date, assessing the staining quality in electron microscopy requires running a sample through the entire staining protocol end-to-end, which can take weeks or ...[more]
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