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Multi-modal adaptor-clathrin contacts drive coated vesicle assembly

ABSTRACT:

SUBMITTER: Corinne J Smith

PROVIDER: EMPIAR-10784 | biostudies-other |

REPOSITORIES: biostudies-other

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Multi-modal adaptor-clathrin contacts drive coated vesicle assembly.

Smith Sarah M SM Larocque Gabrielle G Wood Katherine M KM Morris Kyle L KL Roseman Alan M AM Sessions Richard B RB Royle Stephen J SJ Smith Corinne J CJ

The EMBO journal 20210906 19

Clathrin-coated pits are formed by the recognition of membrane and cargo by the AP2 complex and the subsequent recruitment of clathrin triskelia. A role for AP2 in coated-pit assembly beyond initial clathrin recruitment has not been explored. Clathrin binds the β2 subunit of AP2, and several binding sites have been identified, but our structural knowledge of these interactions is incomplete and their functional importance during endocytosis is unclear. Here, we analysed the cryo-EM structure of ...[more]

PMID: 34487371

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