Dataset Information
Cryo-EM micrographs of human ABCA1
Ontology highlight
ABSTRACT:
SUBMITTER: Tian Xie
PROVIDER: EMPIAR-10798 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of the Human Lipid Exporter ABCA1.
Cell 20170608 7
ABCA1, an ATP-binding cassette (ABC) subfamily A exporter, mediates the cellular efflux of phospholipids and cholesterol to the extracellular acceptor apolipoprotein A-I (apoA-I) for generation of nascent high-density lipoprotein (HDL). Mutations of human ABCA1 are associated with Tangier disease and familial HDL deficiency. Here, we report the cryo-EM structure of human ABCA1 with nominal resolutions of 4.1 Å for the overall structure and 3.9 Å for the massive extracellular domain. The nucleoti ...[more]