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Cryo electron micrographs of Pol delta-PCNA-DNA-FEN1 sample


ABSTRACT:

SUBMITTER: Claudia Lancey 

PROVIDER: EMPIAR-10823 | biostudies-other |

REPOSITORIES: biostudies-other

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In eukaryotes, DNA polymerase δ (Pol δ) bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. We present the high-resolution cryo-EM structure of the human processive Pol δ-DNA-PCNA complex in the absence and presence of FEN1. Pol δ is anchored to one of the three PCNA monomers through the C-terminal domain of the catalytic subunit. The catalytic core sits on top of  ...[more]

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