FIB-SEM of mouse optic nerve of an inducible conditional Mbp knock-out 16 weeks after induction
Ontology highlight
ABSTRACT:
SUBMITTER: Wiebke Möbius
PROVIDER: EMPIAR-10906 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
White matter integrity in mice requires continuous myelin synthesis at the inner tongue.
Meschkat Martin M Steyer Anna M AM Weil Marie-Theres MT Kusch Kathrin K Jahn Olaf O Piepkorn Lars L Agüi-Gonzalez Paola P Phan Nhu Thi Ngoc NTN Ruhwedel Torben T Sadowski Boguslawa B Rizzoli Silvio O SO Werner Hauke B HB Ehrenreich Hannelore H Nave Klaus-Armin KA Möbius Wiebke W
Nature communications 20220304 1
Myelin, the electrically insulating sheath on axons, undergoes dynamic changes over time. However, it is composed of proteins with long lifetimes. This raises the question how such a stable structure is renewed. Here, we study the integrity of myelinated tracts after experimentally preventing the formation of new myelin in the CNS of adult mice, using an inducible Mbp null allele. Oligodendrocytes survive recombination, continue to express myelin genes, but they fail to maintain compacted myelin ...[more]
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