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Cryo-electron tomographs of mouse thalamus neurons

ABSTRACT:

SUBMITTER: Hana Nedozralova

PROVIDER: EMPIAR-10922 | biostudies-other |

REPOSITORIES: biostudies-other

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In situ cryo-electron tomography reveals local cellular machineries for axon branch development.

Nedozralova Hana H Basnet Nirakar N Ibiricu Iosune I Bodakuntla Satish S Biertümpfel Christian C Mizuno Naoko N

The Journal of cell biology 20220309 4

Neurons are highly polarized cells forming an intricate network of dendrites and axons. They are shaped by the dynamic reorganization of cytoskeleton components and cellular organelles. Axon branching allows the formation of new paths and increases circuit complexity. However, our understanding of branch formation is sparse due to the lack of direct in-depth observations. Using in situ cellular cryo-electron tomography on primary mouse neurons, we directly visualized the remodeling of organelles ...[more]

PMID: 35262630

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