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Cryogenic electron microscopy of somatostatin receptor 2/SST14/Gi3 complex

ABSTRACT:

SUBMITTER: Georgios Skiniotis

PROVIDER: EMPIAR-10931 | biostudies-other |

REPOSITORIES: biostudies-other

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Plasticity in ligand recognition at somatostatin receptors.

Robertson Michael J MJ Meyerowitz Justin G JG Panova Ouliana O Borrelli Kenneth K Skiniotis Georgios G

Nature structural & molecular biology 20220224 3

Somatostatin is a signaling peptide that plays a pivotal role in physiologic processes relating to metabolism and growth through its actions at somatostatin receptors (SSTRs). Members of the SSTR subfamily, particularly SSTR2, are key drug targets for neuroendocrine neoplasms, with synthetic peptide agonists currently in clinical use. Here, we show the cryogenic-electron microscopy structures of active-state SSTR2 in complex with heterotrimeric G<sub>i3</sub> and either the endogenous ligand SST ...[more]

PMID: 35210615

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