In situ architecture of the lipid transport protein VPS13C at ER-lysosomes membrane contacts
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ABSTRACT:
SUBMITTER: Shujun Cai
PROVIDER: EMPIAR-10962 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
In situ architecture of the lipid transport protein VPS13C at ER-lysosome membrane contacts.
Cai Shujun S Wu Yumei Y Guillén-Samander Andrés A Hancock-Cerutti William W Liu Jun J De Camilli Pietro P
Proceedings of the National Academy of Sciences of the United States of America 20220713 29
VPS13 is a eukaryotic lipid transport protein localized at membrane contact sites. Previous studies suggested that it may transfer lipids between adjacent bilayers by a bridge-like mechanism. Direct evidence for this hypothesis from a full-length structure and from electron microscopy (EM) studies in situ is still missing, however. Here, we have capitalized on AlphaFold predictions to complement the structural information already available about VPS13 and to generate a full-length model of human ...[more]
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