Ontology highlight
ABSTRACT:
SUBMITTER: Jue Chen
PROVIDER: EMPIAR-11010 | biostudies-other |
REPOSITORIES: biostudies-other
Kieuvongngam Virapat V Chen Jue J
Proceedings of the National Academy of Sciences of the United States of America 20220101 4
ATP-binding cassette (ABC) transporters are ubiquitous molecular pumps that transport a broad range of substrates across biological membranes. Although the structure and function of ABC transporters has been studied extensively, our understanding of their energetics and dynamics remains limited. Here, we present studies of the peptidase-containing ABC transporter 1 (PCAT1), a polypeptide processing and secretion ABC transporter that functions via the classic alternating access mechanism. PCAT1 i ...[more]