Dataset Information
Cryo-electron microscopy reconstruction of ATP-bound human P-glycoprotein
Ontology highlight
ABSTRACT:
SUBMITTER: Jue Chen
PROVIDER: EMPIAR-10803 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation.
Science (New York, N.Y.) 20180125 6378
The multidrug transporter permeability (P)-glycoprotein is an adenosine triphosphate (ATP)-binding cassette exporter responsible for clinical resistance to chemotherapy. P-glycoprotein extrudes toxic molecules and drugs from cells through ATP-powered conformational changes. Despite decades of effort, only the structures of the inward-facing conformation of P-glycoprotein are available. Here we present the structure of human P-glycoprotein in the outward-facing conformation, determined by cryo-el ...[more]