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Cryo-EM structure of Bacillus subtilis RNA Polymerase elongation complex


ABSTRACT:

SUBMITTER: Gokhan Tolun 

PROVIDER: EMPIAR-11051 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Molecular basis for RNA polymerase-dependent transcription complex recycling by the helicase-like motor protein HelD.

Newing Timothy P TP   Oakley Aaron J AJ   Miller Michael M   Dawson Catherine J CJ   Brown Simon H J SHJ   Bouwer James C JC   Tolun Gökhan G   Lewis Peter J PJ  

Nature communications 20201218 1


In bacteria, transcription complexes stalled on DNA represent a major source of roadblocks for the DNA replication machinery that must be removed in order to prevent damaging collisions. Gram-positive bacteria contain a transcription factor HelD that is able to remove and recycle stalled complexes, but it was not known how it performed this function. Here, using single particle cryo-electron microscopy, we have determined the structures of Bacillus subtilis RNA polymerase (RNAP) elongation and H  ...[more]

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