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Cryo-EM structure of DgpB-C at 2.85 angstrom resolution

ABSTRACT:

SUBMITTER: Naruhiko Adachi

PROVIDER: EMPIAR-11124 | biostudies-other |

REPOSITORIES: biostudies-other

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C-Glycoside metabolism in the gut and in nature: Identification, characterization, structural analyses and distribution of C-C bond-cleaving enzymes.

Mori Takahiro T Kumano Takuto T He Haibing H Watanabe Satomi S Senda Miki M Moriya Toshio T Adachi Naruhiko N Hori Sanae S Terashita Yuzu Y Kawasaki Masato M Hashimoto Yoshiteru Y Awakawa Takayoshi T Senda Toshiya T Abe Ikuro I Kobayashi Michihiko M

Nature communications 20211102 1

C-Glycosides, in which a sugar moiety is linked via a carbon-carbon (C-C) bond to a non-sugar moiety (aglycone), are found in our food and medicine. The C-C bond is cleaved by intestinal microbes and the resulting aglycones exert various bioactivities. Although the enzymes responsible for the reactions have been identified, their catalytic mechanisms and the generality of the reactions in nature remain to be explored. Here, we present the identification and structural basis for the activation of ...[more]

PMID: 34728636

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