Dataset Information
Cryo-electron microscopy of human exostosin-like 3 (EXTL3) in the presence of UDP
Ontology highlight
ABSTRACT:
SUBMITTER: Louis Frederick Lundy Wilson
PROVIDER: EMPIAR-11182 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis.
Nature communications 20220608 1
Heparan sulfate is a highly modified O-linked glycan that performs diverse physiological roles in animal tissues. Though quickly modified, it is initially synthesised as a polysaccharide of alternating β-D-glucuronosyl and N-acetyl-α-D-glucosaminyl residues by exostosins. These enzymes generally possess two glycosyltransferase domains (GT47 and GT64)-each thought to add one type of monosaccharide unit to the backbone. Although previous structures of murine exostosin-like 2 (EXTL2) provide insigh ...[more]