Cryo-EM structure of the RhlR-PqsE complex from Pseudomonas aeruginosa
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ABSTRACT:
SUBMITTER: J Ryan Feathers
PROVIDER: EMPIAR-11247 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of the RhlR-PqsE complex from Pseudomonas aeruginosa reveals mechanistic insights into quorum-sensing gene regulation.
Feathers J Ryan JR Richael Erica K EK Simanek Kayla A KA Fromme J Christopher JC Paczkowski Jon E JE
Structure (London, England : 1993) 20221114 12
Pseudomonas aeruginosa is an opportunistic pathogen that is responsible for thousands of deaths every year in the United States. P. aeruginosa virulence factor production is mediated by quorum sensing, a mechanism of bacterial cell-cell communication that relies on the production and detection of signal molecules called autoinducers. In P. aeruginosa, the transcription factor receptor RhlR is activated by a RhlI-synthesized autoinducer. We recently showed that RhlR-dependent transcription is enh ...[more]
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