Ontology highlight
ABSTRACT:
SUBMITTER: Alexandru Radu Aricescu
PROVIDER: EMPIAR-11256 | biostudies-other |
REPOSITORIES: biostudies-other
Masiulis Simonas S Desai Rooma R Uchański Tomasz T Serna Martin Itziar I Laverty Duncan D Karia Dimple D Malinauskas Tomas T Zivanov Jasenko J Pardon Els E Kotecha Abhay A Steyaert Jan J Miller Keith W KW Aricescu A Radu AR
Nature 20190102 7740
Type-A γ-aminobutyric (GABA<sub>A</sub>) receptors are ligand-gated chloride channels with a very rich pharmacology. Some of their modulators, including benzodiazepines and general anaesthetics, are among the most successful drugs in clinical use and are common substances of abuse. Without reliable structural data, the mechanistic basis for the pharmacological modulation of GABA<sub>A</sub> receptors remains largely unknown. Here we report several high-resolution cryo-electron microscopy structu ...[more]