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Tau Paired Helical Filament from Alzheimer's Disease not incubated with EGCG

ABSTRACT:

SUBMITTER: Peng Ge

PROVIDER: EMPIAR-11303 | biostudies-other |

REPOSITORIES: biostudies-other

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Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro.

Seidler Paul M PM Murray Kevin A KA Boyer David R DR Ge Peng P Sawaya Michael R MR Hu Carolyn J CJ Cheng Xinyi X Abskharon Romany R Pan Hope H DeTure Michael A MA Williams Christopher K CK Dickson Dennis W DW Vinters Harry V HV Eisenberg David S DS

Nature communications 20220916 1

Alzheimer's disease (AD) is the consequence of neuronal death and brain atrophy associated with the aggregation of protein tau into fibrils. Thus disaggregation of tau fibrils could be a therapeutic approach to AD. The small molecule EGCG, abundant in green tea, has long been known to disaggregate tau and other amyloid fibrils, but EGCG has poor drug-like properties, failing to fully penetrate the brain. Here we have cryogenically trapped an intermediate of brain-extracted tau fibrils on the kin ...[more]

PMID: 36114178

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