Ontology highlight
ABSTRACT:
SUBMITTER: Carrettiero DC
PROVIDER: S-EPMC2768429 | biostudies-other | 2009 Feb
REPOSITORIES: biostudies-other
The Journal of neuroscience : the official journal of the Society for Neuroscience 20090201 7
Tau inclusions are a prominent feature of many neurodegenerative diseases including Alzheimer's disease. Their accumulation in neurons as ubiquitinated filaments suggests a failure in the degradation limb of the Tau pathway. The components of a Tau protein triage system consisting of CHIP/Hsp70 and other chaperones have begun to emerge. However, the site of triage and the master regulatory elements are unknown. Here, we report an elegant mechanism of Tau degradation involving the cochaperone BAG ...[more]