Dataset Information
Ubiquitinated FANCI in complex with FANCD2 and double-stranded DNA
Ontology highlight
ABSTRACT:
SUBMITTER: Kimon Lemonidis
PROVIDER: EMPIAR-11372 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination.
The EMBO journal 20221117 3
Di-monoubiquitination of the FANCI-FANCD2 (ID2) complex is a central and crucial step for the repair of DNA interstrand crosslinks via the Fanconi anaemia pathway. While FANCD2 ubiquitination precedes FANCI ubiquitination, FANCD2 is also deubiquitinated at a faster rate than FANCI, which can result in a FANCI-ubiquitinated ID2 complex (I<sub>Ub</sub> D2). Here, we present a 4.1 Å cryo-EM structure of I<sub>Ub</sub> D2 complex bound to double-stranded DNA. We show that this complex, like ID2<sub> ...[more]