Principles of mitoribosomal small subunit assembly in eukaryotes
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ABSTRACT:
SUBMITTER: Chloe Burnside
PROVIDER: EMPIAR-11313 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Principles of mitoribosomal small subunit assembly in eukaryotes.
Harper Nathan J NJ Burnside Chloe C Klinge Sebastian S
Nature 20221208 7946
Mitochondrial ribosomes (mitoribosomes) synthesize proteins encoded within the mitochondrial genome that are assembled into oxidative phosphorylation complexes. Thus, mitoribosome biogenesis is essential for ATP production and cellular metabolism<sup>1</sup>. Here we used cryo-electron microscopy to determine nine structures of native yeast and human mitoribosomal small subunit assembly intermediates, illuminating the mechanistic basis for how GTPases are used to control early steps of decoding ...[more]
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