Dog beta3 adrenergic receptor bound to mirabegron in complex with a miniGs heterotrimer
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ABSTRACT:
SUBMITTER: Osamu Nureki
PROVIDER: EMPIAR-11352 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structure of the β3-adrenergic receptor reveals the molecular basis of subtype selectivity.
Nagiri Chisae C Kobayashi Kazuhiro K Tomita Atsuhiro A Kato Masahiko M Kobayashi Kan K Yamashita Keitaro K Nishizawa Tomohiro T Inoue Asuka A Shihoya Wataru W Nureki Osamu O
Molecular cell 20210726 15
The β<sub>3</sub>-adrenergic receptor (β<sub>3</sub>AR) is predominantly expressed in adipose tissue and urinary bladder and has emerged as an attractive drug target for the treatment of type 2 diabetes, obesity, and overactive bladder (OAB). Here, we report the cryogenic electron microscopy structure of the β<sub>3</sub>AR-G<sub>s</sub> signaling complex with the selective agonist mirabegron, a first-in-class drug for OAB. Comparison of this structure with the previously reported β<sub>1</sub>A ...[more]
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