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Cryo-EM structure of Macrophomina phaseolina macrophomene synthase

ABSTRACT:

SUBMITTER: Naruhiko Adachi 

PROVIDER: EMPIAR-11409 | biostudies-other |

REPOSITORIES: biostudies-other

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All known triterpenes are generated by triterpene synthases (TrTSs) from squalene or oxidosqualene<sup>1</sup>. This approach is fundamentally different from the biosynthesis of short-chain (C<sub>10</sub>-C<sub>25</sub>) terpenes that are formed from polyisoprenyl diphosphates<sup>2-4</sup>. In this study, two fungal chimeric class I TrTSs, Talaromyces verruculosus talaropentaene synthase (TvTS) and Macrophomina phaseolina macrophomene synthase (MpMS), were characterized. Both enzymes use dimet  ...[more]

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