HMP1/alpha-catenin binding with actin filaments
Ontology highlight
ABSTRACT:
SUBMITTER: Rangarajan Srinivasan Erumbi
PROVIDER: EMPIAR-11440 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The nematode α-catenin ortholog, HMP1, has an extended α-helix when bound to actin filaments.
Rangarajan Erumbi S ES Smith Emmanuel W EW Izard Tina T
The Journal of biological chemistry 20221217 2
The regulation of cell-cell junctions during epidermal morphogenesis ensures tissue integrity, a process regulated by α-catenin. This cytoskeletal protein connects the cadherin complex to filamentous actin at cell-cell junctions. The cadherin-catenin complex plays key roles in cell physiology, organism development, and disease. While mutagenesis of Caenorhabditis elegans cadherin and catenin shows that these proteins are key for embryonic morphogenesis, we know surprisingly little about their st ...[more]
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