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SJ25C1 Fab in complex with soluble CD19

ABSTRACT:

SUBMITTER: Joel R Meyerson

PROVIDER: EMPIAR-11442 | biostudies-other |

REPOSITORIES: biostudies-other

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CD19 CAR antigen engagement mechanisms and affinity tuning.

He Changhao C Mansilla-Soto Jorge J Khanra Nandish N Hamieh Mohamad M Bustos Victor V Paquette Alice J AJ Garcia Angus Andreina A Shore Derek M DM Rice William J WJ Khelashvili George G Sadelain Michel M Meyerson Joel R JR

Science immunology 20230303 81

Chimeric antigen receptor (CAR) T cell therapy relies on T cells that are guided by synthetic receptors to target and lyse cancer cells. CARs bind to cell surface antigens through an scFv (binder), the affinity of which is central to determining CAR T cell function and therapeutic success. CAR T cells targeting CD19 were the first to achieve marked clinical responses in patients with relapsed/refractory B cell malignancies and to be approved by the U.S. Food and Drug Administration (FDA). We rep ...[more]

PMID: 36867678

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