Microtubule depolymerization contributes to spontaneous neurotransmitter release
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ABSTRACT:
SUBMITTER: Llobet Artur
PROVIDER: EMPIAR-11445 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Microtubule depolymerization contributes to spontaneous neurotransmitter release in vitro.
Velasco Cecilia D CD Santarella-Mellwig Rachel R Schorb Martin M Gao Li L Thorn-Seshold Oliver O Llobet Artur A
Communications biology 20230505 1
Microtubules are key to multiple neuronal functions involving the transport of organelles, however, their relationship to neurotransmitter release is still unresolved. Here, we show that microtubules present in the presynaptic compartment of cholinergic autaptic synapses are dynamic. To investigate how the balance between microtubule growth and shrinkage affects neurotransmission we induced synchronous microtubule depolymerization by photoactivation of the chemical inhibitor SBTub3. The conseque ...[more]
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