Ontology highlight
ABSTRACT:
SUBMITTER: Groffen AJ
PROVIDER: S-EPMC2846320 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Groffen Alexander J AJ Martens Sascha S Díez Arazola Rocío R Cornelisse L Niels LN Lozovaya Natalia N de Jong Arthur P H AP Goriounova Natalia A NA Habets Ron L P RL Takai Yoshimi Y Borst J Gerard JG Brose Nils N McMahon Harvey T HT Verhage Matthijs M
Science (New York, N.Y.) 20100211 5973
Synaptic vesicle fusion in brain synapses occurs in phases that are either tightly coupled to action potentials (synchronous), immediately following action potentials (asynchronous), or as stochastic events in the absence of action potentials (spontaneous). Synaptotagmin-1, -2, and -9 are vesicle-associated Ca2+ sensors for synchronous release. Here we found that double C2 domain (Doc2) proteins act as Ca2+ sensors to trigger spontaneous release. Although Doc2 proteins are cytosolic, they functi ...[more]