Ex vivo murine AApoAII amyloid fibril
Ontology highlight
ABSTRACT:
SUBMITTER: Matthias Schmidt
PROVIDER: EMPIAR-11525 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Insights into the Structural Basis of Amyloid Resistance Provided by Cryo-EM Structures of AApoAII Amyloid Fibrils.
Andreotti Giada G Baur Julian J Ugrina Marijana M Pfeiffer Peter Benedikt PB Hartmann Max M Wiese Sebastian S Miyahara Hiroki H Higuchi Keiichi K Schwierz Nadine N Schmidt Matthias M Fändrich Marcus M
Journal of molecular biology 20240108 4
Amyloid resistance is the inability or the reduced susceptibility of an organism to develop amyloidosis. In this study we have analysed the molecular basis of the resistance to systemic AApoAII amyloidosis, which arises from the formation of amyloid fibrils from apolipoprotein A-II (ApoA-II). The disease affects humans and animals, including SAMR1C mice that express the C allele of ApoA-II protein, whereas other mouse strains are resistant to development of amyloidosis due to the expression of o ...[more]
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