Dataset Information
HIV-1 capsid lattice assembled on 30-nm liposome scaffolds in the presence of assembly cofactor IP6 (pH 7.4)
Ontology highlight
ABSTRACT:
SUBMITTER: Robert A Dick
PROVIDER: EMPIAR-11572 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural insights into HIV-1 polyanion-dependent capsid lattice formation revealed by single particle cryo-EM.
Proceedings of the National Academy of Sciences of the United States of America 20230424 18
The HIV-1 capsid houses the viral genome and interacts extensively with host cell proteins throughout the viral life cycle. It is composed of capsid protein (CA), which assembles into a conical fullerene lattice composed of roughly 200 CA hexamers and 12 CA pentamers. Previous structural analyses of individual CA hexamers and pentamers have provided valuable insight into capsid structure and function, but detailed structural information about these assemblies in the broader context of the capsid ...[more]