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Defective HIV-1 capsid lattice assembled on 30-nm liposome scaffolds in the absence of assembly cofactor IP6

ABSTRACT:

SUBMITTER: Robert A Dick 

PROVIDER: EMPIAR-11575 | biostudies-other |

REPOSITORIES: biostudies-other

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Structural insights into HIV-1 polyanion-dependent capsid lattice formation revealed by single particle cryo-EM.

Highland Carolyn M CM   Tan Aaron A   Ricaña Clifton L CL   Briggs John A G JAG   Dick Robert A RA  

Proceedings of the National Academy of Sciences of the United States of America 20230424 18

The HIV-1 capsid houses the viral genome and interacts extensively with host cell proteins throughout the viral life cycle. It is composed of capsid protein (CA), which assembles into a conical fullerene lattice composed of roughly 200 CA hexamers and 12 CA pentamers. Previous structural analyses of individual CA hexamers and pentamers have provided valuable insight into capsid structure and function, but detailed structural information about these assemblies in the broader context of the capsid  ...[more]

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