Ontology highlight
ABSTRACT:
SUBMITTER: Robert A Dick
PROVIDER: EMPIAR-11575 | biostudies-other |
REPOSITORIES: biostudies-other
Highland Carolyn M CM Tan Aaron A Ricaña Clifton L CL Briggs John A G JAG Dick Robert A RA
Proceedings of the National Academy of Sciences of the United States of America 20230424 18
The HIV-1 capsid houses the viral genome and interacts extensively with host cell proteins throughout the viral life cycle. It is composed of capsid protein (CA), which assembles into a conical fullerene lattice composed of roughly 200 CA hexamers and 12 CA pentamers. Previous structural analyses of individual CA hexamers and pentamers have provided valuable insight into capsid structure and function, but detailed structural information about these assemblies in the broader context of the capsid ...[more]