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Escherichia coli 70S ribosome in complex with P-site tRNAIle(LAU) bound to the cognate AUA codon (Structure IV)

ABSTRACT:

SUBMITTER: Matthieu G Gagnon

PROVIDER: EMPIAR-11585 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Structures of the ribosome bound to EF-Tu-isoleucine tRNA elucidate the mechanism of AUG avoidance.

Rybak Mariia Yu MY Gagnon Matthieu G MG

Nature structural & molecular biology 20240327 5

The frequency of errors upon decoding of messenger RNA by the bacterial ribosome is low, with one misreading event per 1 × 104 codons. In the universal genetic code, the AUN codon box specifies two amino acids, isoleucine and methionine. In bacteria and archaea, decoding specificity of the AUA and AUG codons relies on the wobble avoidance strategy that requires modification of C34 in the anticodon loop of isoleucine transfer RNAIleCAU (tRNAIleCAU< ...[more]

PMID: 38538914

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