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Cryo-EM micrographs of NBD–ffsy filaments

ABSTRACT:

SUBMITTER: Fengbin Wang

PROVIDER: EMPIAR-11619 | biostudies-other |

REPOSITORIES: biostudies-other

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Cell spheroid creation by transcytotic intercellular gelation.

Guo Jiaqi J Wang Fengbin F Huang Yimeng Y He Hongjian H Tan Weiyi W Yi Meihui M Egelman Edward H EH Xu Bing B

Nature nanotechnology 20230522 9

Cell spheroids bridge the discontinuity between in vitro systems and in vivo animal models. However, inducing cell spheroids by nanomaterials remains an inefficient and poorly understood process. Here we use cryogenic electron microscopy to determine the atomic structure of helical nanofibres self-assembled from enzyme-responsive D-peptides and fluorescent imaging to show that the transcytosis of D-peptides induces intercellular nanofibres/gels that potentially interact with fibronectin to enabl ...[more]

PMID: 37217766

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