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Cryo-EM micrographs of AD tau filaments with PET ligand Flortaucipir

ABSTRACT:

SUBMITTER: Sjors HW Scheres

PROVIDER: EMPIAR-11750 | biostudies-other |

REPOSITORIES: biostudies-other

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Cryo-EM Structures of Chronic Traumatic Encephalopathy Tau Filaments with PET Ligand Flortaucipir.

Shi Yang Y Ghetti Bernardino B Goedert Michel M Scheres Sjors H W SHW

Journal of molecular biology 20230616 11

Positron emission tomography (PET) imaging allows monitoring the progression of amyloid aggregation in the living brain. [<sup>18</sup>F]-Flortaucipir is the only approved PET tracer compound for the visualisation of tau aggregation. Here, we describe cryo-EM experiments on tau filaments in the presence and absence of flortaucipir. We used tau filaments isolated from the brain of an individual with Alzheimer's disease (AD), and from the brain of an individual with primary age-related tauopathy ( ...[more]

PMID: 37330290

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