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FMRFa-bound Malacoceros FaNaC1 in lipid nanodiscs in presence of diminazene

ABSTRACT:

SUBMITTER: Cristina Paulino

PROVIDER: EMPIAR-11634 | biostudies-other |

REPOSITORIES: biostudies-other

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Structural basis for excitatory neuropeptide signaling.

Kalienkova Valeria V Dandamudi Mowgli M Paulino Cristina C Lynagh Timothy T

Nature structural & molecular biology 20240209 4

Rapid signaling between neurons is mediated by ligand-gated ion channels, cell-surface proteins with an extracellular ligand-binding domain and a membrane-spanning ion channel domain. The degenerin/epithelial sodium channel (DEG/ENaC) superfamily is diverse in terms of its gating stimuli, with some DEG/ENaCs gated by neuropeptides, and others gated by pH, mechanical force or enzymatic activity. The mechanism by which ligands bind to and activate DEG/ENaCs is poorly understood. Here we dissected ...[more]

PMID: 38337033

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