Dataset Information
Single particle cryo-EM dataset of Bos taurus mitochondrial complex I (originally purified in LMNG) proteoliposomes and deactivated
Ontology highlight
ABSTRACT:
SUBMITTER: Judy Hirst
PROVIDER: EMPIAR-11637 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I.
Science (New York, N.Y.) 20240613 6701
Respiratory complex I is an efficient driver for oxidative phosphorylation in mammalian mitochondria, but its uncontrolled catalysis under challenging conditions leads to oxidative stress and cellular damage. Ischemic conditions switch complex I from rapid, reversible catalysis into a dormant state that protects upon reoxygenation, but the molecular basis for the switch is unknown. We combined precise biochemical definition of complex I catalysis with high-resolution cryo-electron microscopy str ...[more]