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Single particle cryo-EM dataset of Bos taurus mitochondrial complex I (initially solubilised in DDM) proteoliposomes


ABSTRACT:

SUBMITTER: Judy Hirst 

PROVIDER: EMPIAR-11638 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Molecular mechanism of the ischemia-induced regulatory switch in mammalian complex I.

Grba Daniel N DN   Wright John J JJ   Yin Zhan Z   Fisher William W   Hirst Judy J  

Science (New York, N.Y.) 20240613 6701


Respiratory complex I is an efficient driver for oxidative phosphorylation in mammalian mitochondria, but its uncontrolled catalysis under challenging conditions leads to oxidative stress and cellular damage. Ischemic conditions switch complex I from rapid, reversible catalysis into a dormant state that protects upon reoxygenation, but the molecular basis for the switch is unknown. We combined precise biochemical definition of complex I catalysis with high-resolution cryo-electron microscopy str  ...[more]

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