Dataset Information
Single particle cryo-EM dataset of bovine complex I in the deactive state
Ontology highlight
ABSTRACT:
SUBMITTER: Hannah R Bridges
PROVIDER: EMPIAR-11653 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of the Deactive State of Mammalian Respiratory Complex I.
Structure (London, England : 1993) 20180126 2
Complex I (NADH:ubiquinone oxidoreductase) is central to energy metabolism in mammalian mitochondria. It couples NADH oxidation by ubiquinone to proton transport across the energy-conserving inner membrane, catalyzing respiration and driving ATP synthesis. In the absence of substrates, active complex I gradually enters a pronounced resting or deactive state. The active-deactive transition occurs during ischemia and is crucial for controlling how respiration recovers upon reperfusion. Here, we se ...[more]