Dataset Information
Single particle cryo-EM dataset of mouse mitochondrial complex I in the active state
Ontology highlight
ABSTRACT:
SUBMITTER: Hannah Ruth Bridges
PROVIDER: EMPIAR-11648 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states.
Nature structural & molecular biology 20180618 7
Complex I (NADH:ubiquinone oxidoreductase) uses the reducing potential of NADH to drive protons across the energy-transducing inner membrane and power oxidative phosphorylation in mammalian mitochondria. Recent cryo-EM analyses have produced near-complete models of all 45 subunits in the bovine, ovine and porcine complexes and have identified two states relevant to complex I in ischemia-reperfusion injury. Here, we describe the 3.3-Å structure of complex I from mouse heart mitochondria, a biomed ...[more]