Ontology highlight
ABSTRACT:
SUBMITTER: Remi Jo Ruedas
PROVIDER: EMPIAR-11665 | biostudies-other |
REPOSITORIES: biostudies-other
Ruedas Rémi R Vuillemot Rémi R Tubiana Thibault T Winter Jean-Marie JM Pieri Laura L Arteni Ana-Andreea AA Samson Camille C Jonic Slavica S Mathieu Magali M Bressanelli Stéphane S
Journal of structural biology 20240507 2
Single particle analysis from cryogenic transmission electron microscopy (cryo-EM) is particularly attractive for complexes for which structure prediction remains intractable, such as antibody-antigen complexes. Here we obtain the detailed structure of a particularly difficult complex between human epidermal growth factor receptor 2 (HER2) and the antigen-binding fragments from two distinct therapeutic antibodies binding to distant parts of the flexible HER2, pertuzumab and trastuzumab (HTP). We ...[more]