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Atomic structure and conformational variability of the HER2-trastuzumab-pertuzumab complex


ABSTRACT:

SUBMITTER: Remi Jo Ruedas 

PROVIDER: EMPIAR-11665 | biostudies-other |

REPOSITORIES: biostudies-other

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Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex.

Ruedas Rémi R   Vuillemot Rémi R   Tubiana Thibault T   Winter Jean-Marie JM   Pieri Laura L   Arteni Ana-Andreea AA   Samson Camille C   Jonic Slavica S   Mathieu Magali M   Bressanelli Stéphane S  

Journal of structural biology 20240507 2


Single particle analysis from cryogenic transmission electron microscopy (cryo-EM) is particularly attractive for complexes for which structure prediction remains intractable, such as antibody-antigen complexes. Here we obtain the detailed structure of a particularly difficult complex between human epidermal growth factor receptor 2 (HER2) and the antigen-binding fragments from two distinct therapeutic antibodies binding to distant parts of the flexible HER2, pertuzumab and trastuzumab (HTP). We  ...[more]

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