Short and capped F-actin raw data from Structures of the free and capped ends of the actin filament
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ABSTRACT:
SUBMITTER: Roberto Dominguez
PROVIDER: EMPIAR-11684 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structures of the free and capped ends of the actin filament.
Carman Peter J PJ Barrie Kyle R KR Rebowski Grzegorz G Dominguez Roberto R
Science (New York, N.Y.) 20230525 6651
The barbed and pointed ends of the actin filament (F-actin) are the sites of growth and shrinkage and the targets of capping proteins that block subunit exchange, including CapZ at the barbed end and tropomodulin at the pointed end. We describe cryo-electron microscopy structures of the free and capped ends of F-actin. Terminal subunits at the free barbed end adopt a "flat" F-actin conformation. CapZ binds with minor changes to the barbed end but with major changes to itself. By contrast, subuni ...[more]
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