Unknown

Dataset Information

0

Cryo-EM structure of Bicarbonate-bound human Anion Exchanger 1

ABSTRACT:

SUBMITTER: Daniel Wacker 

PROVIDER: EMPIAR-11725 | biostudies-other |

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Anion exchanger 1 (AE1), a member of the solute carrier (SLC) family, is the primary bicarbonate transporter in erythrocytes, regulating pH levels and CO<sub>2</sub> transport between lungs and tissues. Previous studies characterized its role in erythrocyte structure and provided insight into transport regulation. However, key questions remain regarding substrate binding and transport, mechanisms of drug inhibition and modulation by membrane components. Here we present seven cryo-EM structures i  ...[more]

Similar Datasets

Unknown Cryo-EM structure of DIDS-bound human Anion Exchanger 1
| EMPIAR-11726 | biostudies-other
Unknown Cryo-EM structure of Dipyridamole-bound human Anion Exchanger 1
| EMPIAR-11728 | biostudies-other
Unknown Cryo-EM structure of H2DIDS-bound human Anion Exchanger 1
| EMPIAR-11760 | biostudies-other
Unknown Cryo-EM structure of Niflumic Acid-bound human Anion Exchanger 1
| EMPIAR-11727 | biostudies-other
Unknown Cryo-EM structure of the sodium-driven chloride/bicarbonate exchanger NDCBE.
| S-EPMC8478935 | biostudies-literature
Unknown Cryo-EM structure of human Anion Exchanger 1
| EMPIAR-11713 | biostudies-other
Unknown Cryo-EM structure of human Anion Exchanger 1 modified with Diethyl Pyrocarbonate (DEPC)
| EMPIAR-11729 | biostudies-other
Unknown Cryo-EM structure of substrate-bound human telomerase holoenzyme.
| S-EPMC6223129 | biostudies-literature
Unknown Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
| S-EPMC8054211 | biostudies-literature
Genomics Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations
2021-05-20 | GSE148235 | GEO