Unknown

Dataset Information

0

Cryo-EM structure of human Anion Exchanger 1 modified with Diethyl Pyrocarbonate (DEPC)

ABSTRACT:

SUBMITTER: Daniel Wacker 

PROVIDER: EMPIAR-11729 | biostudies-other |

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Anion exchanger 1 (AE1), a member of the solute carrier (SLC) family, is the primary bicarbonate transporter in erythrocytes, regulating pH levels and CO<sub>2</sub> transport between lungs and tissues. Previous studies characterized its role in erythrocyte structure and provided insight into transport regulation. However, key questions remain regarding substrate binding and transport, mechanisms of drug inhibition and modulation by membrane components. Here we present seven cryo-EM structures i  ...[more]

Similar Datasets

Unknown Cryo-EM structure of human Anion Exchanger 1
| EMPIAR-11713 | biostudies-other
Unknown Cryo-EM structure of Bicarbonate-bound human Anion Exchanger 1
| EMPIAR-11725 | biostudies-other
Unknown Cryo-EM structure of DIDS-bound human Anion Exchanger 1
| EMPIAR-11726 | biostudies-other
Unknown Cryo-EM structure of Dipyridamole-bound human Anion Exchanger 1
| EMPIAR-11728 | biostudies-other
Unknown Cryo-EM structure of H2DIDS-bound human Anion Exchanger 1
| EMPIAR-11760 | biostudies-other
Unknown Cryo-EM structure of Niflumic Acid-bound human Anion Exchanger 1
| EMPIAR-11727 | biostudies-other
Unknown Cryo-EM structure of the sodium-driven chloride/bicarbonate exchanger NDCBE.
| S-EPMC8478935 | biostudies-literature
Unknown Cryo-EM structures of human organic anion transporting polypeptide OATP1B1.
| S-EPMC10709409 | biostudies-literature
Unknown Cryo-EM structure of human mitochondrial HSPD1.
| S-EPMC7814154 | biostudies-literature
Unknown Cryo-EM structure of native human thyroglobulin.
| S-EPMC8748809 | biostudies-literature