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Single particle Cryo EM of the LRRK2 I2020T mutant bound to GZD-824

ABSTRACT:

SUBMITTER: Andres Leschziner

PROVIDER: EMPIAR-11869 | biostudies-other |

REPOSITORIES: biostudies-other

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Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures.

Sanz Murillo Marta M Villagran Suarez Amalia A Dederer Verena V Chatterjee Deep D Alegrio Louro Jaime J Knapp Stefan S Mathea Sebastian S Leschziner Andres E AE

Science advances 20231201 48

Mutations in leucine-rich repeat kinase 2 (LRRK2) are a common cause of familial Parkinson's disease (PD) and a risk factor for the sporadic form. Increased kinase activity was shown in patients with both familial and sporadic PD, making LRRK2 kinase inhibitors a major focus of drug development efforts. Although much progress has been made in understanding the structural biology of LRRK2, there are no available structures of LRRK2 inhibitor complexes. To this end, we solved cryo-electron microsc ...[more]

PMID: 38039358

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