Cryo EM of ABC transporter KpsMT(E151Q) in complex with KpsE - ATP-bound state
Ontology highlight
ABSTRACT:
SUBMITTER: Jochen Zimmer
PROVIDER: EMPIAR-12028 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Molecular insights into capsular polysaccharide secretion.
Kuklewicz Jeremi J Zimmer Jochen J
Nature 20240403 8009
Capsular polysaccharides (CPSs) fortify the cell boundaries of many commensal and pathogenic bacteria<sup>1</sup>. Through the ABC-transporter-dependent biosynthesis pathway, CPSs are synthesized intracellularly on a lipid anchor and secreted across the cell envelope by the KpsMT ABC transporter associated with the KpsE and KpsD subunits<sup>1,2</sup>. Here we use structural and functional studies to uncover crucial steps of CPS secretion in Gram-negative bacteria. We show that KpsMT has broad s ...[more]
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