Ontology highlight
ABSTRACT:
SUBMITTER: Sun S
PROVIDER: S-EPMC5520056 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Sun Shan S Li Lin L Yang Fan F Wang Xiaojing X Fan Fenghui F Yang Mengyi M Chen Chunlai C Li Xueming X Wang Hong-Wei HW Sui Sen-Fang SF
Nature communications 20170717
The cellular ESCRT-III (endosomal sorting complex required for transport-III) and Vps4 (vacuolar protein sorting 4) comprise a common machinery that mediates a variety of membrane remodelling events. Vps4 is essential for the machinery function by using the energy from ATP hydrolysis to disassemble the ESCRT-III polymer into individual proteins. Here, we report the structures of the ATP-bound Vps4<sup>E233Q</sup> hexamer and its complex with the cofactor Vta1 (vps twenty associated 1) at resolut ...[more]